Made by you.
Bottled by us.
Hypochlorous acid is what your own immune cells release to keep things clean. Nefense holds it in a pH balanced base, so your nose can use it every day.

Four things are true of it at once, and the last one is the point.
When a threat appears, neutrophils generate hypochlorous acid through the enzyme myeloperoxidase, as part of the innate immune response.
HOCl disrupts microbial cell walls and proteins on contact, and is well tolerated by human tissue at the right concentration and pH.
Pharmaceutical grade HOCl in a pH balanced, isotonic base, so the cleansing action is the same on the last spray as on the first.
A mist flushes dust, pollen and airborne particulates from the nasal lining. No decongestant, so no rebound and no drowsiness.
One ingredient, and three deliberate absences.
A growing nose is more sensitive than an adult one.
Hypochlorous acid is one chlorine and one hydrogen bonded to an oxygen. It is small, it carries no charge, and that is the whole reason it works the way it does.
In water HOCl sits in balance with the hypochlorite ion, and below roughly pH 6 the active HOCl form dominates. That is why the formula is pH balanced rather than simply mixed, and why it is held in isotonic saline: the nose is asked to accept something close to what it already contains.
HypoNasal HOCl Nasal Spray, HypoNasal Junior HOCl Nose Spray and HypoBaby HOCl Nasal Mist.

Everyday nasal cleansing, at the adult strength.

The same formula, held gentler for a child's nose.

The gentlest of the three, made for infants.
The applicator is a long, soft nozzle, so the mist lands where it is meant to rather than at the tip of the nose.
Once
Before the first use, press until a fine mist appears. It stays ready from then on.
Every time
Spray gently into each nostril as needed. There is no daily limit and no waiting period between uses.
Morning and evening, after being outdoors, after travel, or any time your nose feels congested or irritated.
Your own neutrophils make it, through the enzyme myeloperoxidase (opens in a new tab), as part of the innate immune response. The molecule is small and carries no charge, so it reaches microbial cell walls and disrupts proteins on contact. Published reviews of hypochlorous acid (opens in a new tab) describe that antimicrobial action alongside good tolerance by human tissue at the right concentration and pH.
Yes. There is no medication and no steroid in it, and it is made for routine daily cleansing. Because the formula is isotonic and pH balanced to 5.5, close to what the nasal lining already contains, there is no rebound congestion and no stinging. There is no daily limit and no waiting period between uses.
Research into hypochlorous acid in wound care (opens in a new tab) discusses its part in the inflammatory response. That is science about the molecule, not a claim about this bottle. Nefense sprays hold no medication and no steroid, are not sold as an anti-inflammatory, and are not intended to treat any condition. What they do is rinse the nasal lining with a pH balanced solution.
A decongestant constricts blood vessels to open the airway, and with overuse it can cause rebound congestion. This does not decongest. It cleanses: a fine mist flushes away dust, pollen and airborne particulates, then leaves. There is nothing in it your nose can come to depend on, which is why there is no limit on how often you use it.
It is not a treatment for any of them, and nothing here is. Nefense is nasal hygiene: a mist that flushes pollen, dust and airborne particulates off the nasal lining, which is where they land. Through allergy season, or through cold and flu season, that is a cleaning routine rather than a remedy. Ask a clinician about symptoms.
There is a spray made for each. HypoNasal Jr is held at 50 ppm for kids and HypoBaby at 40 ppm for infants, the same formula at a strength set for a smaller and more sensitive nose. As with any nasal product, check with your pediatrician before using it with a baby or a young child.
Everyday nasal cleansing, in a strength made for the nose it is for.
