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Natural Wellness & Defense
Elevate your wellness routine with the power of Hypochlorous Acid. Your body’s natural defense, for clean, effective daily protection.
Hypochlorous acid, the same molecule your own immune cells make, cleanses without the burn.
No alcohol, fragrance, or steroids. pH balanced, isotonic saline you can use every day.
From HypoBaby for infants to HypoNasal for adults, a spray formulated for each stage.
Flush away dust, pollen, and particulates before they settle in, for clean and effective protection.
SHOP THE FAMILY
Looking for the best nasal spray or daily nasal care? Nefense offers all natural Hypochlorous Acid Nasal Spray and Xylitol Nasal Spray, designed to support a clean, fresh and comfortable nasal routine.




Real CT scan comparison showing visible improvement in nasal airway openness using HypoNasal.


Trusted by ENT specialists. Fast, effective, and non-invasive, HypoNasal is nasal care redefined.
Explore HypoNasalCredit: Dr. Geoffrey Skinner, DDS. Individual results vary.
Simple nasal breathing can support a more comfortable and natural way to breathe.
Your nose naturally filters, warms, and humidifies the air you breathe.
Keeping nasal airflow clear helps support comfortable everyday breathing.

Hypochlorous acid (HOCl) is produced by your own immune cells, and it is a molecule studied for its antimicrobial properties.
In an isotonic, pH balanced saline base, HOCl cleanses deeply without the burn of harsh sprays.
A quick spray flushes away dust, pollen, and particulates before they settle in.
Dentists, physicians and hygienists on using Nefense in their own practices and at home.
Rated 5 out of 5
This stuff is like magic. I recommend it to everyone I know. I have been traveling a ton, sick staff and sick kids- and have only got one minor cold all year!!! I carry it with me and use it multiple times a day. It also has allowed me to stop taking any kind of allergy medicine because of its effectiveness in the reduction of inflammation. 💪🙏🏻 Thank you @Richard Downs DDS
Rated 5 out of 5
Thank you for spreading the HOCL word!! It will save many families, patients, and office staff from staying up late with their sick children and friends. Prevention is priceless!
Rated 5 out of 5
Over the past year, I’ve been incorporating HypoNasal into my practice as part of a holistic approach to treating patients with chronic snoring, nasal congestion, and sleep-related concerns. I’ve found it to be highly effective both as a stand-alone product—especially during allergy season—and as an adjunct to other therapies, including NightLase treatments for sleep apnea.
What sets HypoNasal apart is its accessibility, safety, and non-habit-forming formula. It's something I can confidently recommend not just as a part of an in-office protocol, but also for patients to use at home. Whether someone is dealing with seasonal allergies or more persistent nasal blockages, HypoNasal supports better breathing and, by extension, better sleep.
It’s become a go-to recommendation in my toolkit—natural, gentle, and effective.
Rated 5 out of 5
As a dentist focused on treating Airway, Breathing, and Sleep (ABS) disorders, I take a whole-body approach to patient care. Many of my patients struggle to breathe properly through their noses due to allergies, inflammation, congestion, or nasal obstruction. We know that healthy nasal breathing is fundamental to overall health, sleep quality, airway function, and wellness.
As part of our treatment protocols, we provide a nasal hygiene and breathing program that includes Xyloclean and Hyponasal. These products help cleanse, moisturize, and support the health of the nasal passages while providing antimicrobial and anti-inflammatory benefits. Since incorporating these sprays into our protocols, we have seen significant improvements in our patients' ability to breathe more clearly and comfortably through their noses.
For my patients with nasal valve compromise or collapse, I may also recommend an external nasal dilator, such as Intake Breathing, to further improve nasal airflow and breathing efficiency.
Together, these simple yet effective tools have become an important part of helping our patients breathe better, sleep better, feel better and improve their overall quality of life.
Rated 5 out of 5
I have tried Hyponasal and now made it part of my daily self-care regimen. It seems to open up nasal passages, moisturize nasal tissues and calm inflammation. Pollen is especially high this year and since taking Hyponasal, it quiets the allergic symptoms of the seasonal allergies. I really like the bottle as delivery is much more controlled and directed than the usual nasal sprays. I thought the price was reasonable especially for relief provided.
Rated 5 out of 5
For over six months now, my wife, our children, and I have been faithfully using HypoNasal—and I can confidently say, it has completely changed our lives. For years, we battled allergies that not only disrupted our daily routines but also affected our overall well-being. Personally, I dealt with brain fog and episodes of dizziness that, at times, made it hard to stay sharp and focused in the work I’m called to do. But since using HypoNasal, all of that has completely vanished.
This isn’t just a product—it’s a breakthrough. Our allergies are gone. My clarity has returned. My energy is restored. It’s as if the lights have been turned back on, and I’m finally functioning at full capacity—physically, mentally, and spiritually. Watching the transformation in my family—our kids breathing clearly, sleeping better, and enjoying life without allergy symptoms—has been nothing short of a miracle.
I am forever grateful for my dear friend, Dr. Rick Downs, not just for his medical innovation, but for his heart, his integrity, and his unwavering dedication to helping families like mine live healthier, fuller lives.
Thank you, Dr. Rick, for being a vessel of healing and wisdom. HypoNasal has truly been a divine gift to our home.
Rated 5 out of 5
I love xylitol and how it works in every aspect of oral and sinus care. I’ve been a promoter of Xlear nasal spray for decades and I was kind of stumped when I got pushback from people who are afraid of using grapefruit seed extract because of their medication.
Nefense, the new nasal spray series, just came onto the scene. HOCl is the basic ingredient and the xylitol version does not have the grapefruit seed extract in it so, while the amount of the extract is very small, for those who are worried, there is now a solution. Our patients like it. Nefense acts on the mucus and reduces swelling, two major impediments to breathing good breathing.
Rated 5 out of 5
I’ve had several patients start using Hyponasal and really notice a difference with things like seasonal allergies, congestion, headaches, sleep, and just breathing easier overall. Sometimes the small things that improve airflow and breathing can make a much bigger difference than people expect.
I also love that it’s simple to use and easy to work into a daily routine. Anything that helps patients feel and function better naturally is always a win in my book. Such a great addition to my practice.
Questions, answered
A Hypochlorous Acid nasal spray uses HOCl in a nasal formulation designed for cleansing and routine nasal care. HOCl is also produced naturally by immune cells in the body. Research has evaluated low-concentration HOCl nasal irrigation (opens in a new tab) in people with allergic rhinitis. Hyponasal brings HOCl into Nefense’s drug-free nasal-care lineup for consumers looking for a simple everyday nasal spray care option.
Saline nasal spray mainly rinses and moisturizes the nasal passages, while xylitol formulas add a naturally occurring sugar alcohol studied in nasal irrigation. Research comparing Xylitol vs saline (opens in a new tab) has found improvements in sinonasal symptoms with xylitol in certain study groups. Xyloclean offers xylitol-based nasal care for people searching for a drug-free alternative for everyday cleansing, moisture, and nasal comfort support.
The best nasal spray for everyday use depends on age, ingredients, and what you want from nasal care. Medicated decongestant sprays (opens in a new tab) are generally intended for short-term use, while drug-free saline, Hypochlorous Acid, and xylitol formulas may fit routine nasal-care needs. Nefense offers Hyponasal, Xyloclean, Hyponasal Junior, and Hypobaby so families can choose an age-appropriate formula and follow labeled directions carefully.
When choosing a Kids nasal spray, look for age-appropriate labeling, application, clear directions, and ingredients suited to routine nasal care. Saline nasal irrigation (opens in a new tab) has been studied in infants and children for nasal symptoms associated with upper respiratory infections. Nefense offers Hyponasal Junior for children and Hypobaby for babies, giving parents age-specific options instead of relying on an adult nasal spray.
During allergy season, nasal cleansing may help wash away pollen and other particles from nasal passages. A randomized study (opens in a new tab) evaluated low-concentration Hypochlorous Acid nasal irrigation in perennial allergic rhinitis and described HOCl as having anti-inflammatory and antimicrobial properties. Hyponasal can be positioned as an HOCl-based nasal-care option without directly claiming that it treats, prevents, or cures allergies or allergic rhinitis.
Cold and flu season increases interest in nasal cleansing and antimicrobial nasal spray searches. Saline nasal spray is commonly used for moisture and comfort during colds, and CDC guidance (opens in a new tab) includes saline spray or drops among supportive measures. Research also describes low-concentration HOCl as antimicrobial (opens in a new tab), but that does not mean an HOCl nasal spray prevents, treats, or cures colds or influenza.